Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study [EPIC-Norfolk眼研究中的青光眼和眼内压：横断面研究]

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BMJ 2017; 358 doi: https://doi.org/10.1136/bmj.j3889 (Published 13 September 2017)
Cite this as: BMJ 2017;358:j3889

Authors
Michelle P Y Chan, David C Broadway, Anthony P Khawaja, Jennifer L Y Yip, David F Garway-Heath, Jennifer M Burr, Robert Luben, Shabina Hayat, Nichola Dalzell, Kay-Tee Khaw, Paul J Foster

Abstract
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma.

Design Community based cross sectional observational study.

Setting EPIC-Norfolk cohort in Norwich and the surrounding rural and urban areas.

Participants 8623 participants aged 48-92 recruited from the community who underwent ocular examination to identify glaucoma.

Main outcome measures Prevalence and characteristics of glaucoma, distribution of IOP, and the sensitivity and specificity of IOP for case finding for glaucoma.

Results The mean IOP in 8401 participants was 16.3 mm Hg (95% confidence interval 16.2 mm Hg to 16.3 mm Hg; SD 3.6 mm Hg). In 363 participants (4%), glaucoma was present in either eye; 314 (87%) had primary open angle glaucoma. In the remaining participants, glaucoma was suspected in 607 (7%), and 863 (10.0%) had ocular hypertension. Two thirds (242) of those with glaucoma had previously already received the diagnosis. In 76% of patients with newly diagnosed primary open angle glaucoma (83/107), the mean IOP was under the threshold for ocular hypertension (21 mm Hg). No one IOP threshold provided adequately high sensitivity and specificity for diagnosis of glaucoma.

Conclusions In this British community, cases of glaucoma, suspected glaucoma, and ocular hypertension represent a large number of potential referrals to the hospital eye service. The use of IOP for detection of those with glaucoma is inaccurate and probably not viable.