Impact of statin related media coverage on use of statins: interrupted time series analysis with UK primary care data[他汀类药物相关媒体报道对他汀类药物使用的影响：对英国初级保健数据进行时间序列分析]

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BMJ 2016; 353 doi: http://dx.doi.org/10.1136/bmj.i3283 (Published 28 June 2016)
Cite this as: BMJ 2016;353:i3283

Authors
Anthony Matthews, Emily Herrett, Antonio Gasparrini, Tjeerd Van Staa, Ben Goldacre, Liam Smeeth, Krishnan Bhaskaran

Abstract
Objective: To quantify how a period of intense media coverage of controversy over the risk:benefit balance of statins affected their use.

Design: Interrupted time series analysis of prospectively collected electronic data from primary care.

Setting: Clinical Practice Research Datalink (CPRD) in the United Kingdom.

Participants: Patients newly eligible for or currently taking statins for primary and secondary cardiovascular disease prevention in each month in January 2011-March 2015.

Main outcome measures: Adjusted odds ratios for starting/stopping taking statins after the media coverage (October 2013-March 2014).

Results: There was no evidence that the period of high media coverage was associated with changes in statin initiation among patients with a high recorded risk score for cardiovascular disease (primary prevention) or a recent cardiovascular event (secondary prevention) (odds ratio 0.99 (95% confidence interval 0.87 to 1.13; P=0.92) and 1.04 (0.92 to 1.18; P=0.54), respectively), though there was a decrease in the overall proportion of patients with a recorded risk score. Patients already taking statins were more likely to stop taking them for both primary and secondary prevention after the high media coverage period (1.11 (1.05 to 1.18; P<0.001) and 1.12 (1.04 to 1.21; P=0.003), respectively). Stratified analyses showed that older patients and those with a longer continuous prescription were more likely to stop taking statins after the media coverage. In post hoc analyses, the increased rates of cessation were no longer observed after six months.

Conclusions: A period of intense public discussion over the risks:benefit balance of statins, covered widely in the media, was followed by a transient rise in the proportion of people who stopped taking statins. This research highlights the potential for widely covered health stories in the lay media to impact on healthcare related behaviour.