Biases in electronic health record data due to processes within the healthcare system: retrospective observational study [医疗系统流程导致的电子健康记录数据中的偏差：回顾性观察研究]

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BMJ 2018; 361 doi: https://doi.org/10.1136/bmj.k1479 (Published 30 April 2018)
Cite this as: BMJ 2018;361:k1479

Authors
Denis Agniel, Isaac S Kohane, Griffin M Weber

Abstract
Objective To evaluate on a large scale, across 272 common types of laboratory tests, the impact of healthcare processes on the predictive value of electronic health record (EHR) data.

Design Retrospective observational study.

Setting Two large hospitals in Boston, Massachusetts, with inpatient, emergency, and ambulatory care.

Participants All 669 452 patients treated at the two hospitals over one year between 2005 and 2006.

Main outcome measures The relative predictive accuracy of each laboratory test for three year survival, using the time of the day, day of the week, and ordering frequency of the test, compared to the value of the test result.

Results The presence of a laboratory test order, regardless of any other information about the test result, has a significant association (P<0.001) with the odds of survival in 233 of 272 (86%) tests. Data about the timing of when laboratory tests were ordered were more accurate than the test results in predicting survival in 118 of 174 tests (68%).

Conclusions Healthcare processes must be addressed and accounted for in analysis of observational health data. Without careful consideration to context, EHR data are unsuitable for many research questions. However, if explicitly modeled, the same processes that make EHR data complex can be leveraged to gain insight into patients’ state of health.