Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study [父亲年龄与围产期结局的关系，2007-2016年：基于美国人群的队列研究]

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BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4372 (Published 31 October 2018)
Cite this as: BMJ 2018;363:k4372

Authors
Yash S Khandwala, Valerie L Baker, Gary M Shaw, David K Stevenson, Ying Lu, Michael L Eisenberg

Abstract
Objective To evaluate the impact of advanced paternal age on maternal and perinatal outcomes in the United States.

Design Retrospective, population based cohort study.

Setting US.

Population 40 529 905 documented live births between 2007 and 2016.

Main outcome measures Primary perinatal outcomes were gestational age, birth weight, Apgar score at five minutes, admission to a neonatal intensive care unit, need for postpartum antibiotics, and seizures. Primary maternal outcomes were gestational diabetes and pre-eclampsia. Secondary outcome was the number of preventable perinatal events.

Results Higher paternal age was associated with an increased risk of premature birth, low birth weight, and low Apgar score. After adjustment for maternal age, infants born to fathers aged 45 years or older had 14% higher odds of premature birth (odds ratio 1.14, 95% confidence interval 1.13 to 1.15), independent of gestational age, and 18% higher odds of seizures (1.18, 0.97 to 1.44) compared with infants of fathers aged 25 to 34 years. The odds of gestational diabetes was 34% higher (1.34, 1.29 to 1.38) in mothers with the oldest partners. 13.2% (95% confidence interval 12.5% to 13.9%) of premature births and 18.2% (17.5% to 18.9%) of gestational diabetes in births associated with older fathers were estimated to be attributable to advanced paternal age.

Conclusions Advanced paternal age is associated with negative effects on both mothers and offspring. Given the relatively low prevalence of advanced paternal age in the US, population level impacts are currently modest. Nevertheless, as advanced paternal age has doubled in the US over the past generation, further investigation is warranted of the impact on birth outcomes and public health.