Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank [氨基葡萄糖的习惯性使用与心血管疾病风险的关系：基于英国生物数据库的前瞻性研究]

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BMJ 2019; 365 doi: https://doi.org/10.1136/bmj.l1628 (Published 14 May 2019)
Cite this as: BMJ 2019;365:l1628

Authors
Hao Ma, Xiang Li, Dianjianyi Sun, Tao Zhou, Sylvia H Ley, Jeanette Gustat, Yoriko Heianza, Lu Qi

Abstract
Objective To prospectively assess the association of habitual glucosamine use with risk of cardiovascular disease (CVD) events.

Design Prospective cohort study.

Setting UK Biobank.

Participants 466 039 participants without CVD at baseline who completed a questionnaire on supplement use, which included glucosamine. These participants were enrolled from 2006 to 2010 and were followed up to 2016.

Main outcome measures Incident CVD events, including CVD death, coronary heart disease, and stroke.

Results During a median follow-up of seven years, there were 10 204 incident CVD events, 3060 CVD deaths, 5745 coronary heart disease events, and 3263 stroke events. After adjustment for age, sex, body mass index, race, lifestyle factors, dietary intakes, drug use, and other supplement use, glucosamine use was associated with a significantly lower risk of total CVD events (hazard ratio 0.85, 95% confidence interval 0.80 to 0.90), CVD death (0.78, 0.70 to 0.87), coronary heart disease (0.82, 0.76 to 0.88), and stroke (0.91, 0.83 to 1.00).

Conclusion Habitual use of glucosamine supplement to relieve osteoarthritis pain might also be related to lower risks of CVD events.